Endocrine Abstracts

Introduction: Gestational Diabetes Mellitus (GDM) has been associated with complications both in the neonate and in the mother; including increased risk of Type 2 Diabetes Mellitus (DM2), obesity, and cardiovascular disease. Fibroblast growth factor 21 (FGF21) is a key regulator of glucose and lipid metabolism. Recently, the relationship between FGF21 and metabolic component diseases such as diabetes mellitus and obesity has been demonstrated. In addition, FGF21 mRNA and prote...

Introduction: Non-alcoholic fatty liver disease (NAFLD) is an emerging disease in Mexico, comprising a spectrum of histopathological findings ranging from simple steatosis to steatohepatitis and cirrhosis. The gold standard continues to be the liver biopsy, but several mathematical indices have been proposed, such as non-invasive techniques, however there are very few studies in our population.Objetive: This study aims to compare mathematical indexes and...

Introduction: Hyponatremia is the most frequent electrolyte disorder found in clinical practice, and has been associated with increased morbimortalty. Hyponatremia is even more common among patients receiving parenteral nutricion(PN), a therapy increasingly in use. However, the morbimortality of hyponatremic patients on PN is unknown.Methods: Retrospective study, selecting all patients receiving PN in a teaching hospital from 01/11/11 to 01/06/12. We eva...

Objective: The aim of this study is to evaluate the effectiveness of once-weekly exenatide on metabolic control, weight, blood pressure, and lipid profile in obese patients with type 2 diabetes (T2DM), and to assess possible predictive factors of response.Material and methods: Retrospective observational study, conducted with adult obese (BMI ≥30 kg/m2) T2DM subjects that had been initiated once-weekly exenatide following routine clinica...

Introduction: In a majority of Spanish hospitals, serum sodium levels (SNa) are determined by indirect electrode methodology (sodium in the liquid fraction of serum) divided by the total serum volume (mmol/l). To avoid over/underestimating SNa, a formula can be applied: SNa corrected for total proteins (TP)=SNa×93 divided by (99.1−(0.7×TP)). Hypoproteinaemia is frequent in patients receiving parenteral nutrition (PN), and is probably related to surgery, acute d...

Introduction: Squamous cell thyroid carcinoma is a very rare malignant epithelial tumour. It presents as rapid growth cervical mass, may affect neighbour structures and sometimes metastasizes other parts of the body. It’s often associated with previous goiter history and occasionally with autoimmune thyroiditis. It can appear pure, as a component of undifferentiated carcinoma, or combined with differentiated carcinoma areas (papillary or follicular).<p class="abstext"...

Introduction: New treatments of diabetes improve global metabolic status beyond glycemic control and achieve weight reduction in many patients.Case reports: We described four case reports to show GLP-1 agonists and dapaglifozin effects on metabolism and weight in patients with type 2 diabetes and obesity.Case 1 (Liraglutide): A 48-year-old man, hypertension, type 2 diabetes and extreme obesity. Baseline visit: treatment enalapril 2...

Introduction: Treatment with Cinacalcet results in decreased uptake of radiopharmaceutical (because of decreased secretory activity of parathyroid glands as shown by previous studies in secondary hyperparathyroidism). This effect has not been studied in patients with primary hyperparathyroidism (PHPT).Objective: Evaluate clinical and MIBI scintigraphy uptake changes of adenomas in patients treated with Cinacalcet.Patients and metho...

Context: Primary hyperparathyroidism (PHPT) is a common endocrine disease, characterized by the chronic elevation of serum calcium (Ca) levels induced by a long-standing increase of PTH concentrations. PHPT includes mild-asymptomatic and symptomatic forms. Cinacalcet is effective in lowering serum Ca levels in PHPT, but is indicated solely in mild-asymptomatic PHPT meeting surgery criteria. Management of non-surgical mild-asymptomatic PHPT is still a debated issue.<p class...

Introduction: Fatal insomnia is a neurodegenerative spongiform prion disease. Presentation can be sporadic or hereditary (autonomal dominant). The latter, FFI, is caused by a mutation in the human prion protein gene on chromosome 20. Affected individuals present a disorderd sleep-wake cycle, dysautonomia and motor signs, with a predominance of lesions in the thalamus. SIADH has been described in two affected patients.Case Study: A 70-year-old woman was r...